By David I. Graham, James A.R. Nicoll, Ian Bone (Eds.)
Creation to Neuropathology 3Ed continues to be an introductory textual content, yet extra scientific fabric has been brought to make it appropriate to neurologists and a few psychiatrists, in addition to pathologists. This comprises the addition of small quantities of textual content all through, plus neuroimages, together with useful MRI, that is in color. moreover, the textual content has been up to date all through with a brand new crew of contributing authors.
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Extra resources for Adams & Graham's Introduction to Neuropathology
Hypothalamic peptides also play an important role in controlling the release of anterior pituitary hormones. The hypothalamus may be damaged by trauma, metabolic and vascular disease or, rarely, by neoplasm. 2). Increased production is associated with pituitary adenomas. Excess growth hormone causes gigantism in children and acromegaly in adults. Increased prolactin causes delayed puberty in children and, in adult females, amenorrhea, galactorrhea and infertility. In males it may be associated with impotence, infertility and, rarely, galactorrhea.
Disease of the anterior thalamic region in the dominant hemisphere may cause dysphasia, inattention and memory impairment. Extension of disease into the subthalamic region may cause a movement disorder that takes the form of wild involuntary movements of the contralateral limbs (hemiballismus). Disease of the medial thalamic region results in impairment of recent memory, apathy, agitation, impaired attention and, occasionally, coma. Extension of the lesion into the midbrain region may result in impairment of ocular movements.
Tremor, however, is a consistent finding in parkinsonism, whether idiopathic or drug-induced. Parkinson’s disease is a consequence of striatal dopamine deficiency and results in degeneration of the pigmented neurons in the pars compacta of the substantia nigra. The tremor characteristically occurs at rest, is coarse in quality and is associated with rigidity and paucity of movement (bradykinesia). The distinction between late onset benign essential tremor and Parkinson’s disease can be clinically difficult and SPECT imaging has proved helpful (Fig.
Adams & Graham's Introduction to Neuropathology by David I. Graham, James A.R. Nicoll, Ian Bone (Eds.)