By Frank J. Dixon
The fiftieth quantity in a monographic sequence on immunology. one of the issues coated listed here are avian T-cell ontogeny, adoptive move of human lymphoid cells to seriously immuno-deficient mice and histamine-releasing elements and cytokine-dependent activation of basophils and mast cells.
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Extra info for Advances in Immunology 50
An alternative interpretation of these studies is given in Section IX. Although there are I-A molecules that are incompetent to present certain Vbse to certain T cell receptors, it is fair to state that there are no known examples of I-E or HLA-DR molecules that fail to present Vbse or bacterial toxic mitogens. Furthermore, it has been shown that E a paired with the AP chain of an incompetent I-A molecule generates a competent allele, implicating polymorphic regions of the A a chain in interaction with Vbse (Anderson and David, 1989).
1991). , 1990, 1991). Thus, the failure of this response is likely to involve the interaction of the TCR with the MHC class I1 molecule, or with the complex of SEB and the MHC class I1 molecule. MHC class I1 molecules could be incompetent to bind Vbse, or they could b e incompetent to present the hound Vbse to a particular T cell receptor, either because the T cell receptor cannot interact simultaneously with both the Vbse and the MHC class I1 molecule for steric reasons, because the MHC class I1 molecule contributes too little binding energy to the interaction, or because bound peptides prevent docking of the T cell receptor with the MHC molecule in a manner that allows the Vbse to bind the Vp-encoded portion of the receptor.
This may be an important clue in searching for Vbse-binding sites on MHC class I1 molecules. The detailed analysis of various types of incompetent MHC class I1 molecules may reveal much about the interaction of the T cell receptor, MHC class 11, and Vbse leading to T cell activation. Vp SELECTIVE ELEMENTS 23 B. THEINVOLVEMENT OF T CELLRECEPTORS AND CORECEPTORS Conventional protein antigens are recognized as a complex of the specific antigenic peptide bound in the major peptide-binding groove on the outer aspect ofthe MHC class I1 molecule (for review, see Davis and Bjorkman, 1988).
Advances in Immunology 50 by Frank J. Dixon