By George Tegos, Eleftherios Mylonakis
Drug resistance is expanding between numerous human pathogenic microorganisms resembling Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as probably the most very important medical demanding situations of this century. elevated common information and worry of those pathogens skill there's a transforming into call for for learn to take on the specter of multidrug resistance. Documenting the most recent learn within the box, this ebook discusses present and promising actions to find new antimicrobials in 5 key components: molecular genetics and platforms microbiology; man made, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and light-weight- and nano-based applied sciences.
Read or Download Antimicrobial drug discovery : emerging strategies PDF
Similar basic science books
The administration of orthopedic an infection is a space of growing to be value in orthopedic surgical procedure. this article presents an entire assessment from uncomplicated study to scientific software and destiny views within the remedy of orthopedic an infection emphasising the position of neighborhood treatment. The extraordinary choice of reviews of the main specialists within the box offers the reader with long-awaited directions for therapy.
Basics of Psychoneuroimmunology Cai track collage of British Columbia, Vancouver, Canada, and Brian E. Leonard nationwide collage of eire, Galway, eire The long-held idea that the fearful, endocrine and immune structures are separate entities has given method to a brand new knowing of human biology.
How do you retain song of uncomplicated info at the proteins you're employed with? the place do you discover info in their physicochemical houses, amino acid sequences, gene association? Are you bored with scanning overview articles, basic papers and databases to find that elusive truth? the recent educational Press FactsBook sequence will fulfill scientists and scientific researchers struggling with info overload.
Particularly written for optometrists, this e-book at the body structure of the attention describes the physiological capabilities of the attention except its functionality as a visible feel organ
- Role of Oxidative Stress in Chronic Diseases
- International Review of Neurobiology. Supplement 1
- Chromosomal instability and aging : basic science and clinical implications
- Afferent Connections of the Medial Basal Hypothalamus
Additional resources for Antimicrobial drug discovery : emerging strategies
Piddock, L. (2006b) Multidrug-resistance efflux pumps – not just for resistance. Nature Reviews Microbiology 20, 629–636. P. and Hill, C. (2009) Discovery of medically significant antibiotics. Current Drug Discovery Technology 6, 1–18. Pitout, J. B. (2008) Extendedspectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infectious Disease 8, 159–166. Plesiat, P. and Nikaido, H. (1992) Outer membranes of Gram-negative bacteria are permeable to steroid probes. Molecular Microbiology 6, 1323–1333.
E. J. (2003) MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds. Bioorganic and Medicinal Chemistry Letters 13, 4205–4208. , Loomis, L. A. (2001) Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzyme. Proceedings of the National Academy of Sciences USA 98, 4107–4112. , Zhu, S. A. (2006) PlyC: a multimeric bacteriophage lysin.
2010) Identification of synthetic inducers and inhibitors of the quorum-sensing regulator LasR in Pseudomonas aeruginosa by high-throughput screening. Applied and Environmental Microbiology 76, 8255–8258. , Korus, R. and Crawford, R. (2003) The determination of the stability constant for the iron(II) complex of the biochelator pyridine-2,6-bis(monothiocarboxylic acid). Biodegradation 14, 73–82. Breukink, E. and De Kruijff, B. (2006) Lipid II as a target for antibiotics. Nature Reviews Drug Discovery 4, 321–332.
Antimicrobial drug discovery : emerging strategies by George Tegos, Eleftherios Mylonakis