Antimicrobial drug discovery : emerging strategies - download pdf or read online

By George Tegos, Eleftherios Mylonakis

ISBN-10: 1845939433

ISBN-13: 9781845939434

Drug resistance is expanding between numerous human pathogenic microorganisms resembling Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as probably the most very important medical demanding situations of this century. elevated common information and worry of those pathogens skill there's a transforming into call for for learn to take on the specter of multidrug resistance. Documenting the most recent learn within the box, this ebook discusses present and promising actions to find new antimicrobials in 5 key components: molecular genetics and platforms microbiology; man made, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and light-weight- and nano-based applied sciences.

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Piddock, L. (2006b) Multidrug-resistance efflux pumps – not just for resistance. Nature Reviews Microbiology 20, 629–636. P. and Hill, C. (2009) Discovery of medically significant antibiotics. Current Drug Discovery Technology 6, 1–18. Pitout, J. B. (2008) Extendedspectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infectious Disease 8, 159–166. Plesiat, P. and Nikaido, H. (1992) Outer membranes of Gram-negative bacteria are permeable to steroid probes. Molecular Microbiology 6, 1323–1333.

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2010) Identification of synthetic inducers and inhibitors of the quorum-sensing regulator LasR in Pseudomonas aeruginosa by high-throughput screening. Applied and Environmental Microbiology 76, 8255–8258. , Korus, R. and Crawford, R. (2003) The determination of the stability constant for the iron(II) complex of the biochelator pyridine-2,6-bis(monothiocarboxylic acid). Biodegradation 14, 73–82. Breukink, E. and De Kruijff, B. (2006) Lipid II as a target for antibiotics. Nature Reviews Drug Discovery 4, 321–332.

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Antimicrobial drug discovery : emerging strategies by George Tegos, Eleftherios Mylonakis


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